A Research Journey

Research & Publications

From Bangalore biofuel labs to Kenyan savannahs to Cambridge pharma - follow the path.

The Journey

Research Positions

Click any milestone to expand.

2023
Biotech R&D R&D Research Intern Sea6 Energy · Bangalore, India
Summer 2023
50+ PCRs
Bangalore, India · Seaweed biofuel R&D
  • Studied Seaweed Carrageenan bioconversion into biopolymers, biostimulants, and platform chemicals alongside a team of PhDs and postdocs
  • Conducted 50+ PCRs for bacterial infection models, HPLC molecular analysis, and evaluated Carrageenan with 5 additives across 9 plant species
Neuroscience Computational Neuroscience Intern Devilbiss Lab · Rowan-Virtua SOM
Jun 2023 - Aug 2024
8 subjects
3-ch EEG · TBI · LC-NE research
  • Research on locus coeruleus-norepinephrine (LC-NE) regulation of neural activity and cognition using 3-channel EEG on 8 animal subjects (4 rabbits, 4 rats) with and without TBI
  • Engineered EEG artifact-removal pipelines: band-pass filtering, ICA for ocular/EMG artifacts, and threshold-based epoch rejection prior to spectral analysis
  • Measured neural dynamics with norepinephrine, dopamine, and Ritalin interventions; analyzed with MATLAB and SpikeOne; directed toward SOM/GSBS publication
2024
Clinical Neurology Medical Assistant & Shadowing Comprehensive Neurology LLC
Summer 2024
50+ patients/day
MRI · EEG · EMG · 8 weeks full-time
  • 8-week program, 40 hrs/week; aided 50+ patients/day and managed WC, MVA, NJ Disability, and surgical precertifications using Practice Fusion EHR
  • Shadowed Drs. Pasupuleti & Zhang - observed cases spanning Parkinson's, Alzheimer's, Epilepsy, MS, and motor neuron disease; interpreted MRI, EEG, and EMG results
NeuroAI NeuroAI Research Intern Hasson Lab · Princeton University
Oct 2024 - Jun 2026
1.5M+ hrs
$50M NIH · 15 families · infant cognition
  • Analyzing 1.5M+ hours of infant cognitive data from 15 families in the 1,000 Days (1kD) Project - a $50M NIH-funded longitudinal study of early brain development
  • Applying Python-based deep learning pipelines and ACLEW tier-dependent annotation frameworks to quantify executive function (EF) and self-regulation markers
  • Filtering confounds and standardizing annotation tiers to build scalable cross-family predictive models for infant neurodevelopment
2025
Field Research Research Assistant - Grevy's Zebra Project Mpala Research Centre · Laikipia, Kenya
Jan 2025 - Present
20+ hrs 4K
Laikipia Plateau · FAA + Kenya certified
  • Examining flee dynamics of Plains and Grevy's Zebras in response to predation pressure using drone footage captured from ~100m altitude over the Laikipia Plateau, Kenya
  • FAA & Kenya-certified drone pilot; captured 20+ hours of 4K footage during a 3-week field collection sprint
  • Applying DeepLabCut and SLEAP to map individual and group-level movement patterns; collaborating with Dr. Craig Marshall and Dr. Isla Duporge on a manuscript for The Naturalist
Clinical Research Research Fellow - Undergraduate Clinical Scholars Program UPenn Perelman School of Medicine
Summer 2025
500+ patients
43% outcome improvement · FMT study
  • Analyzed 500+ patient microbiome datasets in R, Stata, and Excel to evaluate FMT route of administration for severe recurrent Clostridioides difficile infection
  • Identified 43% improvement in patient outcomes with lower GI (enema) FMT vs. upper GI routes; presented to 100+ senior physicians at UCSP symposium
  • Authoring 5 conference abstracts and 2 peer-reviewed manuscripts; completed NIH/NIDDK-backed epidemiology training
AI / ML AI/ML Developer PEMM Department · Princeton University
May - Aug 2025
4,500 paintings
DELLA supercluster · BLIP-2 · CLIP · CoCa
  • Built computer vision pipelines on Princeton's DELLA supercluster to analyze 4,500 Ethiopian paintings and 200,000+ metadata attributes for large-scale art-historical analysis
  • Adapted and fine-tuned BLIP-2, CLIP, and CoCa vision-language models to build a scalable IC|TC classification framework for automated stylistic attribution (First vs. Second Gondar styles)
Data Analysis Data Analyst - Project Xenon AfterQuery Experts
May - Aug 2025
100+ datasets
~80% model accuracy · 1,000+ annotations
  • Analyzed 100+ clinical and economic datasets in Excel, R, and SQL for downstream decision modeling
  • Built labeled training frameworks that improved AI model task performance to ~80% accuracy via statistical modeling, feature engineering, and 1,000+ quality-controlled annotations
Volunteer Care Ambassador - Neurology Department Princeton Medical Center · Penn Medicine
Sep 2025 - Present
150+ hrs
Live hospital neurology · Penn Medicine
  • 150+ volunteer hours supporting nursing workflows, patient interaction, and interdisciplinary clinical teams in the Neurology Department at Princeton Medical Center
2026
Public Health Lead Data Analyst - NJ Mobile Harm Reduction Study Princeton Global Health Program
Feb 2026 - Present
574 responses
14 NJ sites · 28 policy visualizations
  • Lead analyst on a 574-response client survey across 14 New Jersey mobile harm reduction sites - PI: Prof. Heather Howard (SPIA); Lead: Dr. Ben Scher
  • Built the full R/Python pipeline: substance-use profiling, naloxone access cascades, police-interaction modeling, housing-instability risk - surfacing significant racial disparities in naloxone access (OR = 1.74, p < 0.05)
  • Produced 28 policy-facing visualizations informing NJ statewide harm-reduction service-delivery recommendations
Neuroscience Junior Paper & Senior Thesis Researcher Princeton Neuroscience Institute · Brody Lab (Carlos Brody, HHMI)
July 2026 - Present
Neuropixels
mPFC + hippocampus · learning · Princeton
  • Modeling how prefrontal and hippocampal populations reorganize as mice learn a virtual-reality decision task, from chronic Neuropixels recordings in 3 implanted animals tracked across every stage of learning
  • Built the analysis pipeline from single-cell GLMs to population flow-field models (neural SDE + GRU) to capture how task solutions form
  • Adding closed-loop optogenetic hippocampal inhibition to test its causal role in shaping prefrontal dynamics, mirroring adaptive DBS
  • Basis of the junior paper and senior thesis, mentored by Jesse Kaminsky
Neuroscience Research Intern - Adaptive DBS Biomarkers UC Berkeley Weill Neurohub · UCSF Starr Lab
May 2026 - Present
202 recordings
87 patients · Percept LFP · UCSF
  • Built the analysis and review platform behind the lab's full Percept dataset, 202 deep-brain recordings across 87 Parkinson's and dystonia patients, now the tool the team uses to catalogue and annotate every session for adaptive DBS biomarker discovery
  • Showed with patient-nested mixed models that beta power falls as stimulation amplitude rises (-0.90 dB/mA, p < 1e-12), confirming across all 87 patients that the control signal adaptive DBS depends on holds beyond single-patient studies
  • Ran a scan across all 202 recordings for biomarkers invisible to visual review and surfaced the aperiodic 1/f slope, which tracks stimulation second only to canonical beta-burst rate (|r| = 0.58 overall, 0.79 in GPi)
  • Invited to present the findings to the Starr Lab in September 2026
Computational Genomics Research Intern - Gene Evidence Platform Novartis DAx Group · NIBR Cambridge
Summer 2026
20 databases
8 weeks · agentic LLM · NIBR Cambridge
  • Built an end-to-end gene evidence platform in 8 weeks, unifying 20 population-scale genetic databases through Novartis's internal warehouse to surface and rank drug targets
  • Now used daily by the DAx team for gene safety screens and more broadly for target discovery and portfolio triage, replacing a multi-day manual evidence search with an on-demand query
  • Extended it into an agentic LLM system with a hard cite-or-abstain guarantee, where every numeric claim must appear verbatim in its cited source row or the system declines, proven by 1,027 adversarial checks with zero fabrications
  • Found that default query row caps silently dropped 60-94% of the genetic evidence on high-degree genes, and shipped a completeness-preserving fix (see the architecture)
Scholarly Work

Publications in Progress

Seven manuscripts and abstracts - clinical medicine, neuroscience, ecology, genomics, computational art history.

01
Fecal Microbiota Transplantation Route of Administration and Clinical Outcomes in Recurrent Clostridioides difficile Infection
Donthula A. et al. UPenn Perelman · UCSP 2025-2026
Download PDF
02
Flee Dynamics and Social Stratification in Plains and Grevy's Zebra Under Predation Pressure
Donthula A., Marshall C., Duporge I. The Naturalist · Princeton Mpala (~June 2026) In Preparation
Draft available upon request
03
Optogenetic Sweet Neuron Activation Supports Spatial Place Conditioning in Drosophila melanogaster, with Preliminary Evidence for Goal-Directed Outcome Sensitivity
Donthula A. NEU 350 · Princeton University · May 2026 In Preparation
Download GitHub
04
Predictive Modeling of Executive Function Development from Longitudinal Infant Audiovisual Data
Hasson Lab (Donthula A., contributing author) 1,000 Days Project · $50M NIH Program In Preparation
Manuscript in progress
05
LC-NE Regulation of Neural Plasticity and Cognitive Recovery in Traumatic Brain Injury Animal Models
Devilbiss Lab (Donthula A., contributing author) SOM/GSBS · Rowan University In Preparation
Manuscript in progress
06
Effects of Monoclonal and Polyclonal Antibodies on the Active Immune System
Donthula A. Antibody Society Non-Profit Research Abstract
07
Automated Stylistic Attribution of Ethiopian Religious Paintings Using Vision-Language Models
Donthula A., Belcher W. et al. Princeton PEMM · DELLA Supercluster · 2025 In Preparation
Download PEMM ↗